N-CAM Expression: The Study of Muscle Disease in a Tertiary Center of Thailand

Background: Neural cell adhesion molecule (N-CAM), or CD56, is a cell-surface glycoprotein that plays critical role in mediating intercellular the central nervous system. It also found to be expressed on embryonic muscle but disappears healthy adult muscle. However, denervated regenerating muscles can express N-CAM. Objective: To evaluate value of N-CAM expressions diagnosing diseases Thai population. Materials and Methods: The present study used immunohistochemistry interpret expression 75 biopsy specimens diagnosed with myopathies non-myopathies from 3-year retrospective cohort. Results: Using chi-squared test, there was statistically significant associativity between diagnosis inflammatory myopathy, not muscular dystrophy, neurogenic change, non-specific myopathy even though they showed expression. positive 15 out 17 cases statistical significance (p<0.001, OR 14.250, 95% CI 2.960 68.606). authors did find any mitochondrial non-myopathy cases, whose biopsies were defined as control group due lack myopathic change clinical symptoms. Conclusion: suggest evaluation complementary tool have fibers, especially myopathy. Keywords: molecule; N-CAM; CD56; Muscle disease; Myopathy